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Similarly, in Nrf2-KO mice, there are higher levels of proinflammatory genes such as IL-1, IL-6, IL-8, iNOS , and COX-2 , and a decrease in the expression of antioxidant enzymes like hemeoxygenase-1 and GST Mu-1 (93)

Proper site rotation prevents cumulative tissue irritation, and many patients feel minimal discomfort by their third or fourth dose

Glial Cells Associated with Ferroptosis After Ischemic Stroke Iron Overload-Induced Ferroptosis of Glial Cells After Ischemic Stroke Microglia exhibit significantly higher iron levels than neurons, playing an important role in regulating iron homeostasis after cerebral ischemia (Bishop et al