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Serum MDA was also decreased significantly following antioxidant treatment

In the model of acute liver damage induced by APAP, IL-22BP deficient mice increase the infiltration of inflammatory CD11b + Ly6C + monocytes in the liver and increase CXCL10 expression

By integrating suppression of upstream inflammatory signaling with direct inhibition of endothelial CAM expression, these compounds effectively disrupt leukocyte recruitment, preserve renal microcirculation, and limit propagation of inflammatory injury (Bonventre and Yang 2011

Therefore, all peptides inhibited the expression of TNF and pro-inflammatory IL-6 cytokine stimulated by LPS on terminally differentiated THP-1 cells