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In obese individuals, adipose tissue accumulates in the thoracic visceral cavity, chest wall, and diaphragm, reducing the functional residual capacity (FRC) and expiratory reserve volume [84]

Some anecdotal reports of transient headache or mild nausea at higher doses

For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress ( in situ GSH in tumor triggered mCMSNs biodegradation and reduced Cu 2+ into Cu + for enhanced hydroxyl radical production, leading to a powerful inhibition effect on tumors (Liu et al., 2019)

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