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This proteasomal inhibiting role can lead to a reduced proteasomal elimination of ubiquinated P-I (phosphorylated-inhibitor kappa), inhibiting nuclear translocation of NF-, suppressing NF-B activation and its consequences of tumor necrosis factor alpha (TNF-), and NO production ( In addition to inhibiting NF-B, riboflavin inhibits the release and expression of High-mobility group protein B1, a nuclear factor involved in sepsis regulation and other immune-mediated conditions with a critical role in sepsis-associated multiple organ failure (60)

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The cell viability in HG medium with varying concentrations of DAPA (0, 3.125, 6.25, 12.5, 25, 37.5, 50 and 100 mol/l) was evaluated at specific time points

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