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To determine if GSH depletion-induced oxidative stress impairs mitochondrial biogenesis, we used MitoTracker Red to stain live mitochondria

The identification of specific, mutation-dependent metabolic vulnerabilities in particular cancers by targeting them to synergize with radiotherapy, chemotherapy, or immunotherapy to induce cytotoxicity is suggested

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Prophylactic and therapeutic activities in vivo Previous pharmacokinetics studies have revealed that, in humans, co-administration of a 200 mg dose of clofazimine with food results in a C max of 0.41 mg l 1 (equivalent to 0.86 M) at 8 h