napqi and glutathione Acetaminophen metabolism. NAPQI, N-acetyl-p-benzoquinone imine; CYP450, Fasting depletes Glutathione, turning "safe"
Fasting depletes Glutathione, turning "safe" Paracetamol doses into a liver toxic emergency. Don't let a therapeutic dose become a lethal one. See the safety protocols on BMJ Best Practice via bio. #MedEd # First line treatment for acetaminophen overdose: A. Flumazenil B. Naloxone C. N acetylcysteine D. Sodium bicarbonate Solved The following figure shows the metabolism of the Toxicology Rounds : Emergency Medicine News
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