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doi: 10.1016/j.arres.2022.100037 80 ChandranKAggarwalDMigrinoRQJosephJMcAllisterDKonorevEAet al

In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa

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Tissue loading may occur at even lower rates of administration