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Description

Higher doses (4.5 mg) were evaluated but discontinued due to excessive gastrointestinal side effects without proportional benefits[7]

While this property remains partially characterized, it explains reported benefits for conditions involving brain and spinal cord tissue

& Paller, A

demonstrated that anti-depressive effects of fluoxetine or imipramine were lost following x-ray ablation of cell proliferation in the SGZ indicating an important contribution of adult neurogenesis in the mood-modulating effects of 5-HT [132]