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Therefore, the guidelines of professional societies do not recommend the routine use AOXs in treatment of male infertility, mainly due to the heterogeneity of the available data

, Wu D., Wu J., et al

In addition to GSH inhibition, LCS3 is reported to inhibit the activity of thioredoxin reductase1 (TXNRD1), a critical antioxidant regulator maintaining the redox state of thioredoxin (TRX) [19](Supplementary Fig