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Additionally, untargeted metabolomics analysis showed that the differentially expressed metabolites were primarily correlated with lipid metabolism, including steroid hormone biosynthesis (cholesterol sulfate), primary bile acid biosynthesis (cerebrosterol), and sphingolipid metabolism (phytosphingosine) between the control and TYGM groups

Nevertheless, the biological plausibility supported by the polyphenols, omega-3 fatty acids, selenium, and antioxidant components characteristic of the MD suggests that it may represent a feasible and relatively safe adjunctive approach for thyroid-related neurofunctional impairment (203, 211, 212)