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As a 44-amino acid peptide hormone, hGH-RH belongs to a family that includes vasoactive intestinal peptide (VIP), secretin, glucagon, glucagon-like peptides-1 and -2, and gastric inhibitory peptide 54,55,56,57,58

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However, a drug may be toxic in some individuals at concentrations normally tolerated by most other patients

In the largest and longest follow-up study to date (up to 12 months), patients with mild AD underwent FUS targeting the hippocampus, frontal, and parietal lobes, with no serious adverse events, full BBB closure within 48 h, and cognitive outcomes comparable to those seen with natural disease progression (Rezai et al., 2022)