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IV therapy can be particularly beneficial for delivering medications that reduce inflammation, manage pain, or modify the disease process

However, given that increased VIP innervation to the mucus glands in COPD is proposed to contribute to increased sputum production [126], VIP agonists might be of mixed benefit

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In a diabetic nephropathy mouse model overexpressing the receptor for advanced glycation end products (RAGE) and an AGE-induced endothelial-macrophage co-culture injury model, catalpol regulates the RAGE/Ras homolog gene family member A (RhoA)/Rho-associated kinase (ROCK) signaling pathway, interferes with the interaction between macrophages and endothelial cells, reduces endothelial injury and chemokine secretion, inhibits macrophage migration, and restores the M1/M2 phenotypic balance, improving the pathological damage in diabetic nephropathy (Shu, 2021