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It has been reported that aberrant expression of the lipid metabolism differential gene CYP19A1 in CRC is not only a prognostic risk factor for CRC patients but also enhances the ability of activated CD8 + T cells to kill CRC cells by suppressing the expression of PD-L1 in CRC cells [50]

J Cell Biol 217:19852004 Sun H, Zhang J, Xin S, Jiang M, Zhang J, Li Z, Cao Q, Lou H (2019) Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2

Along with the process of -GC synthesis was blocked by BSO, the total contributions of U- 15 N glutamine to GSH was reduced in the established high ACTL6A-expressing PDX tumors, and the levels of [ 15 N]-labeled glutamine and glutamate were thus increased (Fig