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Nature 2018;562, 578-582, doi:10.1038/s41586-018-0543-y

As reviewed above, alterations in intestinal permeability can be complex and multifactorial, offering researchers and clinicians several avenues to aid in disease recognition and diagnosis, investigate pathogenesis, and develop therapies to improve outcome and hopefully, in the future, prevent these diseases from occurring

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Representative images were captured at 5,000 magnification and the images analysed using a method described previously 51,52