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BPC-157 + TB-500, for the cartilage indication Due to the emerging chondroprotective profile of AOD-9604 (Vukmirovic-Popovic 2010), the research literature features the combination with BPC-157 and TB-500 for indications: Osteoarthritis (intra-articular formulation) Tendinopathy Chondral defects in animal models MOTS-c, metabolic support MOTS-c improves mitochondrial efficiency, released fatty acids from AOD-9604-induced lipolysis can then be more efficiently oxidized

These processes can impair neuronal communication, disrupt synaptic plasticity, and contribute to mitochondrial dysfunction, a key factor in cellular energy production

Khan et al., 2015