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Laboratory work-up showed pancytopenia, macrocytosis, acute kidney injury, a high serum folate level of 20 ng/ml and a vitamin B12 level of 127 pg/mL (Table 1)

Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

It is a 29-amino acid polypeptide representing the 129 fragment from endogenous human GHRH, thought to be the shortest fully functional fragment of GHRH

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