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Cell culture studies have shown that NNMT inhibition increases intracellular NAD+ levels, enhances sirtuin activity, and shifts adipocyte metabolism toward greater fatty acid oxidation

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Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy

This observation suggested that the size-transformable P-Mn/TI@mHSA delivery systems could enhance both atherosclerosis binding and plaque penetration, facilitating the effective inward diffusion of the protein nanoclusters toward targeted cells to achieve the desired therapeutic functions