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Additional information Peer review information Nature Communications thanks Maggie Levy and Philippe Simoneau for their contribution to the peer review of this work

Future research should focus on developing non-invasive or minimally invasive sampling methods to improve sample diversity and conduct large multicenter cohort studies to enhance result generalizability

they are made into teas, syrups and jellies, and used to make oils for the complexion

Their potencies against LXR and LXR were evaluated in biochemical binding assays, cellular mammalian two-hybrid interaction assays evaluating nuclear receptor co-repressor (NCOR) recruitment and cellular reporter assays evaluating transcriptional activity (Fig