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Numerous studies suggest that neurotoxins may interact with -synuclein or other proteins connected to Parkinsons disease to influence the etiology of the disease (Klein and Westenberger, 2012)

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M.VestergaardE.JessenN.Kolind-ThomsenP.NellemannB.NielsenT.et al (2019)

This would suggest the role of -arrestin2 in the stabilization of dopamine receptor signaling and overcoming the plasticity induced by chronic levodopa treatment