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The combination of ursolic acid and sorafenib inhibits SLC7A11 and reduces GSH synthesis, while significantly increasing lipid peroxidation levels, inducing ferroptosis in cells, and reversing drug resistance in liver cancer cells, thereby exhibiting significant antitumor activity and providing a new therapeutic strategy for tumor treatment

doi: 10.1016/J.IT.2019.05.001

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Further support for a direct contribution of glutamate in the disease process came from blocking studies, applying Memantine, an N-methyl-D-aspartate (NMDA) ionotropic glutamate receptor antagonist