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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above

Patients in intervention group received intravenous NAC (Exir Pharmaceutical company, Tehran, Iran) 3gr in 250 ml 5% dextrose over 30 min every 6 hours for the first 72 hours of admission (Figure 1)

People who opt for this method often see results in as little as 2 to 3 months of consistent treatment

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