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All the new anti-herpetic compounds summarized in this review appear to be promising and have the potential to significantly enhance therapies for HSV infections

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GSH depletion does not induce mitochondrial superoxide or alter mitochondrial mass in RPE cells It has been suggested that mitochondria are predominant source of ROS upon H 2 O 2 -induced oxidative stress 7

When the body is under oxidative stress, the generation rate of ROS and RNS surpasses the clearance capacity of endogenous antioxidant systems (e.g., the glutathione system), resulting in excessive ROS production, which serves as a key driver of tumor initiation, progression, metastasis, and drug resistance 14