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But chronically inconsistent technique can create a pattern of variable absorption that mimics dose inadequacy or treatment resistance

These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58

These molecules modulate gene expression at transcriptional and post-transcriptional levels, influencing inflammation, oxidative stress, and neuronal repair

Initially used to treat systemic iron overload, iron chelators have subsequently been found to exert neuroprotective effects and cross the bloodbrain barrier [174, 175]