glutathione substrate GSH-Glo™ Assay as well as in their non Team:UNSW Australia/Experiments/Glutathione System

Some describe this as subtle but unmistakable improvement

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However, both the chemical reduction of extracellular cystine by GSH released from astrocytes as well as transfer via extracellular vesicles should not be affected by inhibitors of the astrocytic GT or neuronal aminopeptidase N, which were shown to be involved in the supply of cysteine to neurons (Dringen, Pfeiffer, et al

Their primary strength is the highly technical task of de novo design: exploring vast chemical spaces and meticulously optimizing novel candidates against specific, complex property profiles