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Some ingredients have better evidence than others

Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

Factors such as gut inflammation, enzyme degradation, and first-pass hepatic metabolism drastically reduce the actual percentage of nutrients that reach systemic circulation

It is generally well-tolerated, though comprehensive long-term studies are still limited