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Collectively, the gutbrain, erythrocytebrain, and kidneybrain axes highlight the systemic complexity of PD pathogenesis, where peripheral dysfunction contributes to central neurodegeneration through diverse molecular and cellular pathways

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In a number of experimental and clinical studies, Lipoic acid has now been shown to be useful in the treatment of such conditions as diabetes, ischemia-reperfusion damage, neurodegeneration, heavy-metal poisoning, radiation damage and HIV infection and may offer significant protection against stroke, heart disease and cataracts (Packer L et al., 1995)