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Ketamine has a high lipid solubility that allows rapid passage across the bloodbrain barrier

For hTYR, H161, H183, and H192 chelate CuA, while H344, H348, and H371 chelate CuB

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doi: 10.1245/s10434-018-6662-8 133 MontfortAPearceOManiatiEVincentBGBixbyLBohmSet al