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J Pharmaceut Sci

The critical design choice was the C-terminal PGP extension: Pro-Gly-Pro provides primary resistance to proteolytic degradation, extending the compound's half-life from the minutes range of native ACTH(4-7) to approximately several hours, enabling meaningful and sustained CNS activity following administration

The unresolved question is whether excessive exposure, prolonged use, background food fortification, paternal and maternal methyl-donor status, or individual genetic susceptibility may produce unintended epigenetic effects in a subset of children

3.15: Effects of supplemental chromium (200 g/ day) vs