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Taking any of these medications in combination with vitamin B6 may decrease their effectiveness

The guidelines stipulate a maximum increase of no more than 10 mmol/L in the initial 24 h or 18 mmol/L across any 48-h interval for patients with chronic hyponatremia at low risk of osmotic demyelination syndrome (ODS)

That quick response is one reason injections are often recommended for people with ongoing fatigue or confirmed deficiency