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The proof-of-principle results demonstrating that disruption of AHCY dimerization suppresses tumor growth further suggest that this strategy may complement traditional active-site inhibition and inspire analogous interventions for other metabolic enzymes with moonlighting regulatory functions in cancer

This mechanism was confirmed by the evidence that erythrocytes isolated from smokers exhibited higher levels of membrane-recruited caspase-8 and FADD than non-smokers

Edgren G., Hjalgrim H., Rostgaard K., et al., Transmission of Neurodegenerative Disorders through Blood Transfusion: A Cohort Study, Annals of Internal Medicine 165, no

Vet Immunol Immunopathol 140(34):199206