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In vivo studies indicate that TMAO stimulates the activation of the NLRP3 inflammasome, resulting in the release of IL-1 and IL-18, accelerating renal inflammation and fibrosis [84]

FASEB J 4(6):16241633 Massie A, Schallier A, Mertens B, Vermoesen K, Bannai S, Sato H, Smolders I, Michotte Y (2008) Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats

Other areas of the body that are more sensitive, such as around the eyes, inner thighs, and underarms, should be treated with gentle chemical peels that are catered for delicate skin, such as Mesopeels

Another study with 23 females with sensitive skin found that a 1% Ectoin cream helped to tolerate a 0.5% or 1% retinol treatment much better