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Reproductive toxicity studies of acetylcysteine solution in the rat given oral doses of acetylcysteine solution up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature.1 The only adverse effect observed was a slight non-dose-related reduction in fertility at dose levels of 500 or 1,000 mg/kg/day (2.6 or 5.2 times the human mucolytic dose) in the Segment I study

Small NADs, such as siRNA, and large ones, such as mRNA, in addition to the necessary modifications, still require the aid of delivery vectors

What are the known risks, including the risk of peripheral neuropathy and effects on kidney, liver, and thyroid function

Phosphatidylcholines (PC), a class of phospholipids, are transported by Stard2/PC-TP, Stard7 and Stard10 (Kanno et al, 2007