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Description

Iron-melanin complex in substantianigra of parkinsonian brains: an x-ray microanalysis

Electron tomograms confirm that these ~ 10 nm filaments can be readily distinguished from membrane bilayers (Supplementary Movies 1, 2)

Rev-erb has shown neuroprotective properties in Parkinsons disease, as the loss of its rhythmicity in the substantia nigra of affected patients is associated with exacerbated microglial activation and increased inflammatory markers, conditions that are attenuated following pharmacological reactivation of Rev-erb (Kou et al., 2022)