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it is especially true for autoimmune connective tissue diseases (e.g., SLE), where some off-label therapies (e.g., rituximab) seem to work in selected cases in the everyday clinical routine but failed to show significant differences over placebo in clinical trials ( Despite the fact that there are many differences in the pathogenesis of systemic autoimmune diseases, many aspects are similar, leading to common molecular targets, like type I IFN/IFN receptor, IL-17, GM-CSF receptor, BAFF, CD40/40L, or JAK/STAT ( Table 2 )

Reactive oxygen species (ROS) are compounds that can build up in your cells over time and cause damage (known as oxidative stress) when they reach high enough levels

doi: 10.1016/j.neuroscience.2014.02.053 36 FernellE.BejerotS.WesterlundJ.MiniscalcoC.SimilaH.EylesD.et al

Graphical Abstract Highlights 1 Arsenic exposure reduced feed intake, super oxide dismutase, catalase, and glutathione peroxidase activities and growth in young goats