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However, some individuals may benefit from higher doses depending on their health goals and conditions

One documented case of 15-year patellar tendonitis showed major improvement by weeks 3 to 4, enabling pain-free bodyweight squats for the first time in years

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However, many of these trials were limited by small sample sizes, short intervention durations, heterogeneous dosing protocols, and the potential for placebo effects, which constrain direct clinical extrapolation