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An improved understanding of genetic forms of disease has more recently facilitated the identification of amenable targets for novel gene therapies in subsets of patients with ALS

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[DOI] [PMC free article] [PubMed] [Google Scholar] Nicoll JAR, Roberts GW, Graham DI

Mitophagy is mainly mediated by BCL2/adenovirus E1B 19kDa interacting protein 3/Nip3-like protein X, and Parkin/PINK1 (PTEN induced putative kinase 1) ( 2.2 Immunogenic cell death Immunogenic cell death (ICD), known as immunogenic apoptotic cell death or immunogenic apoptosis, has been defined as a form of regulated cell death that is sufficient to activate an adaptive immune response in immunocompetent hosts ( IR-induced OS can induce immunogenic death of tumor cells through multiple mechanisms ( + T cells and elicited antitumor immunity ( 2.3 Ferroptosis Ferroptosis is another way of radiation-induced tumor cell death, which is caused by lipid peroxidation caused by iron metabolism disorder and ROS accumulation