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On one hand, moderate HO-1 expression can degrade heme to reduce free iron, inhibit NF-KB activation, and alleviate inflammation and oxidative stress ( In addition to NF-KB and Nrf2/HO-1, the NLRP3 inflammasome and cGAS-STING pathways also play distinctive roles in ferroptosisinflammation crosstalk

For example, Ostra rivularis polysaccharides enhance Nrf2/ARE gene expression (142), while Cyaeoleya polysaccharide (CPP) increases Nrf2 while decreasing Keap1 expression, with glycogen synthase kinase-3 (GSK3) acting as an upstream regulator (143)

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