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"By itself, the Blue Zone theory is not regarded as strong science," says Dr

C57/BL6 wild-type mice aged 68 weeks (bodyweight = 2326 g) were acquired from the Wuhan University Center for Animal Experiment

We subsequently determined whether IPA enhances ISC proliferation in organoid assays, determining that no differences in colonic organoid formation and development were present between Veh- and IPA-treated mice at D0, indicating that IPA does not affect ISC proliferation ex vivo in the absence of DSS-induced injury