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A.KoropatkinN

This clearly indicates the significant role of intracellular GSH in the eradication of tumor cells by CDCZA

Current literature predominantly elucidates linker chemistries, cytotoxic payloads, and pharmacokinetics tailored to tumor biology (Long et al., 2025)

Pyruvate enters the mitochondria through mitochondrial pyruvate carriers 1 and 2 (MPC1 and 2), and their genetic depletion or pharmacologic inhibition reduces glucose-stimulated insulin secretion (GSIS) in rodent and human islets (Patterson et al., 2014