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In rare cases, more serious side effects such as infection or allergic reactions may occur

BBR is self-assembled into nanoparticles (100300 nm) with polysaccharides, flavonoids or proteins in traditional Chinese medicine compounds by hydrogen bonds and hydrophobic effects during decoction, which can significantly improve their water solubility (2.35-fold) and intestinal absorption rate (2.64-fold), while reducing the side effects of single components (such as gastrointestinal irritation) ( 9 Toxicity and safety Although BBR is natural and widely used, its potential toxicity cannot be ignored

10.1073/pnas.1215689109 32 DambrovaM.LatkovskisG.KukaJ.StreleI.KonradeI.GrinbergaS.et al (2016)

Diabetes affects more than 400 million adults worldwide ( A key feature of uncontrolled diabetes is high blood sugar levels