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Although GSH cannot be oxidized directly by SOD1 to produce H 2 O 2 , it is apparently capable of reducing cystine to regenerate free CSH: 2GSH + CS-SC GS-SG + 2CSH 53,63

doi: 10.3389/fimmu.2017.01239 Received 27 June 2017 Accepted 19 September 2017 Published 29 September 2017 Volume 8 - 2017 Edited by Anna Rubartelli, IRCCS AOU San Martino IST, Italy Reviewed by Cecilia Garlanda, Istituto Clinico Humanitas, Italy