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[284] findings that heat treatment can modify silver nanoparticles geometrical shape, altering their emitted light spectrum wavelength, help put together the most robust explanation so far as to why clinical argyria provisional resolution, at least, can be obtained despite silver persistence in the skin and emphasizes the need not discard the possibility of argyria relapse even with silver exposure discontinuation

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Pharmacol Rep 66:499504 Packer L, Cadenas E (2011) Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling

doi: 10.1006/jmcc.2002.2082