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Prevalence and Challenges Estimates suggest B12 deficiency affects a significant portion of the population (often cited around 610% or higher depending on criteria), with PA being a major non-dietary cause, especially in older adults

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evidence that selenoproteins may be encoded in the +1 reading frame overlapping the human Cd4, Cd8, and hla-Dr genes

Signs in infants and young children (often appearing around 4-6 months): Irritability and sleep disturbances Developmental delays or regression Poor muscle tone and coordination problems Speech difficulties White matter abnormalities on brain imaging In adults: Movement disorders Balance and coordination problems Cognitive decline and memory loss Mood changes The symptoms can range from mild behavioral changes to severe, progressive neurological deterioration