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A cross-sectional, controlled study on Metformin that included both diabetic and non-diabetes patients showed no that irrespective of Metformin use, no significant difference in the serum levels of vitamin B12 was observed, both in patients with and without diabetes (5)

Bachegowda L, Gligich O, Mantzaris I, Schinke C, Wyville D, Carrillo T, et al

The knowledge about functional expression of transporters at the BBB and structural requirements for substrate binding and translocation via the transporters gives tempting opportunity for rational design and development of drugs, prodrugs and nanocarriers, which can utilize the specific BBB transporter for brain delivery of CNS drugs (71, 72)

Researchers note that while both drugs significantly reduce body weight, their underlying mechanisms differ in scope