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This effect may be due to spike protein inducing negative mitochondrial membrane potential, increasing intracellular calcium, and increasing levels of reactive oxygen species (ROS)

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The results of metabolomics and lipidomics analysis revealed that numerous lipid species in human plasma, including fatty acids, triacylglycerols, glycerophospholipids, sterol lipids, and sphingolipids, are regulated by circadian rhythms [49]

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