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In addition, -synuclein pathology is linked with bioenergetics dysfunction in PD by inhibiting the expression of SIRT1 and the development of aberrant mitochondrial morphology (Yan et al

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EXCLI J 19:1387 Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA (2018) Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating -synuclein transmission and neuroinflammation

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