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Also, there was no typical morphological evidence of apoptosis, including swelling of the cytoplasm and organelles, nor rupture of the cell membrane (Dixon et al., 2012)

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863 (12), 14981510

This slow, steady decline is a natural part of the aging process, but it is often accelerated by the environmental stressors we encounter every dayfrom UV rays and pollution to the simple metabolic byproducts of living an active life

Analysis of oxidative stress markers revealed that dopaminergic loss of neurons is mediated by ROS derived from the metabolism of the neurotransmitter dopamine associated with low levels of glutathione and high levels of essential metals calcium and iron in substantia nigra pars compacta