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The ferroptosis signalling pathway is comprehensive, and in addition to the classical disorders of iron metabolism, the glutathionecysteamineglutathione system and polyunsaturated fatty acid metabolism, an increasing number of signalling pathways, such as nicotinamide adenine dinucleotide phosphate/ferroptosis-inhibitory protein 1 and tetrahydrobiopterin/GPT cycloheximide 1/dihydrofolate reductase, have been identified 51

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The goals of these strategies are typically to restore a healthy microbial community, enhance production of beneficial microbial metabolites, and/or reduce levels of pro-inflammatory or neurotoxic microbial products