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Study characteristics such as sample size (17% of 2 explained, p = 0.01) and ethnicity (31% of 2 , p = 0.02) explained some of the heterogeneity, but source of controls (0% of 2 , p = 0.02) and cancer type ( 2 3 = 5.55, p = 0.14) did not explain much of it

External standard libraries were used to confirm the m / z and retention time for each metabolite

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