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44 These results demonstrate that multiple HECT type E3 ligases concomitantly regulate the expression of p63 and p73, and in the case of Np63, its expression may be dependent on p53 status (Figures 7 and 8)

It is well-known that HP can accelerate DNA ubiquitination and promote the degradation of p53 by the proteasome (pepsinogen I and II

Available online at: May 17, 2025) Summary Keywords Parkinsons disease, human intelligence, artificial intelligence, assessment instruments, ICF framing, ChatGPT4.o, ChatGPT Scholar Citation Anghelescu A, Munteanu C, Spinu A, Ciobanu V, Popescu C, Cioca IE, Andone I, Stoica S-I, Mandu M, Rebedea A, Giuvara S, Malaelea A-D, Vladulescu-Trandafir A-I, Morcov M-V and Onose G (2025) Standardized clinical assessments and advanced AI-driven instruments used to evaluate neurofunctional deficits, including within biomarker based framework, in Parkinsons disease - human intelligence made vs